منابع مشابه
Quiet Down Now: How Excitatory Neurons Inhibit One Another
Draped atop the brain like a wrinkled gray blanket, the cortex is responsible for much of what we perceive, think, and do. It is a couple of square feet in area and only a few millimeters thick, but its millions of neurons form trillions of synaptic connections, making it, hands down, the most complex piece of neural real estate on the planet. Its macroscopic convolutions can only hint at the c...
متن کاملAnother way to break down
hen yeast secretory proteins are improperly folded, the ER quality control system directs them into the HRD/DER pathway, which targets the proteins for degradation. Blocking the HRD/DER pathway, however, does not completely stop degradation, implying that there must be an alternative way to destroy misfolded secretory proteins. Haynes et al., reporting on page 91, have now characterized that pa...
متن کاملGive Me Another One!
We investigate the complexity of an optimization problem in Boolean propositional logic related to information theory: Given a conjunctive formula over a set of relations, find a satisfying assignment with minimal Hamming distance to a given assignment that satisfies the formula (NearestOtherSolution, NOSol). We present a complete classification with respect to the relations admitted in the for...
متن کاملIn E. coli, Interrupting One Death Pathway Leads You Down Another
You might think that organisms would do well to just concentrate on staying alive, and leave death to the fates, but in fact, all eukaryotes have well-regulated programmed cell death pathways built into their genes, which help sculpt organs during development and scuttle infected cells before they get out of control. Bacteria, too, have cell death mechanisms, and, like so much of the bacterial ...
متن کاملOne thing leads to another.
In 1956, the JCI published an article by Vincent Dole on a method for titrating plasma fatty acids that uncovered the importance of fatty acids as a substrate for glucose metabolism. When asked to prepare a historical perspective on this very popular paper, I paid Dole a visit and we reminisced. His answer to my question of how he came to do this work on plasma fatty acids was: "Well, one thing...
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ژورنال
عنوان ژورنال: Index on Censorship
سال: 2001
ISSN: 0306-4220,1746-6067
DOI: 10.1080/03064220108536883